The current worldwide economic downturn is continuing to shrink the number of investigative sites across the globe. The sharpest decline in investigator sites has occurred in Europe according to CenterWatch. The US is not immune to this activity as the most active proportion of principal investigators (PIs) has fallen from 29% to below 23% in the last five years. An even more staggering statistic is the average number of new trials started by the highest-volume sites in the US and Canada which has dropped by 85%. The causes for this are reported as the current economy, budgetary pressures, and regulatory burdens. To find out more about the current state of clinical research investigators click here. To learn how Pearl offers unique service offerings to sponsors, PIs, and CROs, visit here. We are more than just an IRB, offering many wrap around clinical services to our clients.